Heartland BioWorks

Manufacturing biotechnology innovation in human, animal, and plant science

Heartland BioWorks is a biotech manufacturing Regional Tech Hub built of leading-edge companies, research institutions, and government partners and powered by the Applied Research Institute. Awarded funding in July 2024, Heartland BioWorks is a national leader poised to catalyze innovation and entrepreneurship in next-gen biotech for years to come.  

 Indiana leads the nation in pharmaceutical exports

One of the top three states in exports for all life sciences products – pharmaceuticals, medical devices, and agbiosciences — for more than a decade

Indiana is the only state in the nation to manufacture all three COVID-19 vaccines

Why Indiana?

The COVID-19 pandemic was a tipping point for the power of biotechnology to solve emerging problems, yet it exposed the national security risk of America’s reliance on the off-shore manufacturing of bioproducts, with the White House setting the goal of ensuring that bioproducts are both invented and made in the US.

Indiana’s Indianapolis-Carmel-Anderson MSA features the unmatched collection of resources and capabilities necessary to become the world-leading force that realizes the President’s bioeconomy vision. The region is home to landmark industry leaders that span the bioecosystem (e.g., HQs of Lilly, Corteva, Elanco); the nation’s largest medical school and R1 universities focused on biotechnology and manufacturing innovations (e.g., Indiana and Purdue Universities); coordinated state-regional-local prioritization of life sciences to advance economic opportunities; and a rapidly growing venture ecosystem. The Heartland BioWorks Tech Hub (BioWorks) will unite Indiana stakeholders and concentrate their efforts and resources on emerging biotechnology and biomanufacturing.

Supported by meaningful stakeholder commitments, BioWorks will initially focus on four integrated activities that address key barriers in the region: 1) BioTrain (equitable, hands-on workforce development); 2) BioLaunch (networked infrastructure and support for commercialization); 3) BioWorks HQ (training, technology demonstration, and convening facility); and 4) BioWorks Governance (hub coordination infrastructure). BioWorks will initially target the human/animal health sectors. However, within ten years, BioWorks will fuel Indiana’s economy by bridging and accelerating the commercialization of breakthrough technologies in human, animal, and plant biosciences, transforming these into job-creating companies that improve America’s national security, economic future, and dominance in a biotechnology future.





Frequently Asked Questions

What is the Regional Tech Hub program?

The Regional Tech Hub program was created in the CHIPS and Science Act of 2022, which was co-sponsored by Indiana’s own U.S. Senator Todd Young and signed into law by President Joe Biden in August of 2022. In the wake of the legislation’s passage, Senator Young wrote in an op-ed that the CHIPS and Science Act “supercharges funding of basic scientific research and significantly expands STEM education opportunities. And it will establish Regional Tech Hubs across our country to help launch innovative companies, revive American manufacturing, and lay the foundation for new jobs to jumpstart our local communities.” (See https://www.young.senate.gov/newsroom/press-releases/young-releases-op-ed-on-chips-and-science-act.)

According to the Economic Development Administration (EDA), which is implementing the program, “the Tech Hubs Program will make place-based economic development investments to drive technology- and innovation-centric growth by strengthening a region’s capacity to commercialize, manufacture, and deploy critical technologies. This program aims to invest in regions with the assets, resources, capacity, and potential to become globally competitive, within approximately ten years, in the technologies and industries of the future.”

For more detailed questions on the structure of the Regional Tech Hubs program, please visit the EDA’s website found at: https://www.eda.gov/funding/programs/regional-technology-and-innovation-hubs/faq.

How could a Regional Tech Hub benefit Indiana?

Indiana has strong assets in the biologic product development space across industry, academia, government, and non-traditional stakeholders. A Regional Tech Hub designation, and the funding that follows, could help dismantle the silos that currently exist between these partners, allowing for greater collaboration and accelerated innovation.

Indiana stakeholders have described the need for more dedicated manufacturing operations and innovation space. The Regional Tech Hubs program will catalyze further production, which will foster innovation and encourage more businesses to start and grow in Indiana.

Why is ARI leading Indiana’s application for a Regional Tech Hub?

In partnership with the Indiana Economic Development Corporation, and under the direction of Indiana Governor Eric Holcomb, ARI is a neutral third-party innovation orchestrator and does not have vested interests in the Regional Tech Hub program other than to foster the continued growth of Indiana’s innovation economy. This is a critical requirement of any entity tasked with leading a program of this kind. And, with nearly six years successfully pursuing, winning, and executing complex, highly-competitive federal opportunities, ARI is uniquely positioned in the marketplace to lead this initiative.

How do I get involved in Indiana’s application for the Regional Tech Hub Program?

To formally engage with the Indiana Biotechnology Manufacturing Hub, please fill out the intake form located at: https://theari.us/indiana-biotech-hub-connect/.

For general interest or questions, feel free to contact the team at techhub@theari.us.

Why biotech manufacturing?

ARI, in coordination with the Indiana Economic Development Corporation, conducted two parallel analyses of Indiana’s assets to determine what technologies would have the biggest positive economic impact on Indiana and Hoosiers, as well as position the state for a successful Regional Tech Hub application.

The results of each effort reflected Indiana’s vast expertise in both life sciences (Eli Lilly, Elanco, Corteva, Catalent, Cook, Roche, OrthoWorx) and advanced manufacturing (Indiana is the densest state in manufacturing per capita).

Due to its central geography and the strength of its R1 research institutions – and more importantly, its rich history in manufacturing innovation, quality control and regulation – Indiana has an opportunity to emerge as a national leader in the development side of life sciences research and development.

Where would Indiana’s Tech Hub be Located?

The EDA dictates that each Hub will need to select a Metropolitan Statistical Area (MSA) and/or Micropolitan Statistical Area (μSA) that is tightly interconnected as the basis of the Hub. The EDA does permit some activities related to the Hub to occur outside of that geographic area, but the core of the Hub’s activity will be located within the selected statistical area. ARI is currently engaging stakeholders to select the geographic area that will best position the Hub for global competitiveness in biotech manufacturing.


Indiana University School of Medicine is
the largest medical school in the
country with more than 1,400 medical

BioCrossroads is Indiana’s initiative 
to grow the life sciences, a public-private
collaboration that supports the region’s
research and corporate strengths while
encouraging new business development.



Purdue University features the nation’s 
top graduate Agricultural & Biological
Engineering program for 11 years
straight, according to U.S. News & World